International Journal of Medical, Pharmaceutical and Biological Sciences (IJMPBS) has launched today its first issue, April-June 2021. This issue comprises of total seven article which includes one editorial article written by the editor in chief. Anjali Pawar. The abstract of the other articles is summarized below:
1. Title: NANOFIBER AND CANCER - AN OVERVIEW OF RECENT DEVELOPMENTS
Authors: Iyer Aditya Manivannan, Syed Tazib Rahaman
Abstract: Cancer is a disease of grave concern. To combat the alarming need to provide an effective treatment methodology, Nanotechnology has become a powerful tool. It aids in achieving target-specific drug delivery to the tumour site. Nanofibers are among such nano-bio materials that can encapsulate antitumor drugs. In this review we tried to enlist various commercial nano-formulations, comprehend electrospinning as a means of developing nanofibers, brief on natural, semisynthetic and synthetic polymers such as Zein, Chitin, Chitosan, Poly-lactic acid, Poly lactic-co-glycolic acid, and Polycaprolactone suitable for nanofiber preparation, and applications of Nanofibers in delivery of a single drug as well as a combination of drugs or theranostic agents in cancer. It also describes three mechanisms of drug release from nanofibers, namely, pH-responsive, thermoresponsive and magnetic-heat composite release. The review tabulates the recent developments enlightening the applications of nanofibers in cancer chemotherapy in the past two decades. Nanofibrous mats are effective systems for localized treatment involving monotherapy, combination therapy, as well as for concomitant delivery of drugs and imaging agent, or genes. They have potential applications in the prevention of post-surgical cancer recurrence. Nanocomposite systems confer the ability to modulate drug release. Systems like nanoparticles which suffer from poor circulation time can be incorporated within nanofibrous mats. With many such unforeseen advantages and merits, Nanofiber becomes a potential nanotechnology driven system that enables patient-centric therapy for grave conditions like cancer. Read more
2. Title: MORPHOLOGICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF SYZIGIUM CUMINI
Authors: Anjani M. Nikhare, Wrushali A. Panchale, Amar F. Sabhadinde, Jagdish V. Manwar, Ravindra L. Bakal
Abstract: Syzygium cumini, family Myrtaceae, a medicinal plant with numerous pharmacological activities such as anti-diabetic, antioxidant, anti-hyperlipidic and hepatoprotective. Seeds are moderately rich in protein and various phytochemicals along with flavonoids quercetin and, rutin a well-known antioxidant. Its leaves are used to treat leucorrhoea, stomachache, fever, dermopathy, constipation, inhibit blood discharge in feaces and reduce radiation induced DNA damage. Jamun fruit is an effective food remedy for bleeding piles and correcting liver disorders. This will help in confirmation of traditional use along with value-added utility of plant eventually leading to higher revenues from the plant. Read more
3. Title: DEVELOPMENT AND EVALUATION OF TASTE MASKED FORMULATIONS OF FEXOFENADINE HYDROCHLORIDE
Authors: Eshani Pradeep Rane, Meghana Babar
Abstract: Ease of administration and patient compliance is gaining significant importance in the design of dosage forms. Dysphagia (difficulty in swallowing) is a common difficulty among all age groups especially in elderly and pediatrics. Patients suffering from dysphagia show greater chances of being choked during consumption of liquid formulation. Thus, to mollify such a problem, liquid formulation of high viscosity was prepared. The objective of present research work was to design and develop pediatric taste masked formulations of Fexofenadine hydrochloride (FEH) with taste enhancement and improved bioavailability. The masking of bitter taste of the drug was a necessity to formulate it in a palatable form. Effective taste masking of Fexofenadine hydrochloride was achieved through complexation with selected cyclodextrin (2- Hydroxypropyl beta cyclodextrin/ Cavasolw7HP). Inclusion complex prepared by solid dispersion showing taste score 1 (tasteless) was selected and further subjected to in-vitro taste assessment study. Based on human panel studies, tasteless FEH-2HPBCD complex i.e., batch FE5 was selected as optimized batch and different child friendly taste masking technologies were screened for incorporation of the same. Oral flavored powder formulations were prepared by mixing drug-2HPBCD inclusion complex equivalent to 30mg of FEH with varying concentrations of sucralose and with different flavors like chocolate, lemon, cherry, pineapple, etc. Formulation batch contaning lemon flavor F4 was more acceptable to human volunteers. Effervescent granules were formulated by using different concentration of effervescent salts, sucralose and lemon flavor. Soft chewable lozenges were formulated by optimization for binder concentrations and various flavors like chocolate, cherry, lemon, pineapple, etc. Results conclusively demonstrated that successful taste masking of FEH was accomplished and that it could be formulated for oral administration with more acceptability to pediatrics and improved bioavailability. Read more
4. Title: ORALLY DISINTEGRATING FILM: AN INNOVATIVE AND EASY APPROACH
Authors: Mohd Saif Mohd Akram Momin, Neha Inayat Hussain Ansari
Abstract: Orally disintegrating film (ODF) is a novel and simple method for delivering therapeutically or medicinally active chemical substances to the body(s). The major goals of orally disintegrating films (ODFs) are to improve drug’s bioavailability, permeability, and time to action, as well as enhance patient compliance. The process of making films is identical to that of making a transdermal patch. When a film is placed in the mouth, salivary fluid causes it to disintegrate quickly, releasing the medication(s). The medication(s) will subsequently be absorbed into the bloodstream, revealing therapeutic effect. This overview covers the pros and demerits of ODF formulations, as well as formulation aspects, technologies involved in making ODF formulations, and evaluation tests conducted for the same, as well as packing and storage. Orally disintegrating film formulations are a unique dosage form designed to enhance drug delivery, therapeutic action, and patient compliance. Read more
5. Title: COVID-19 VACCINES APPROVED FOR EMERGENCY USE AND UNDER DEVELOPMENT AROUND THE GLOBE – AN OVERVIEW
Abstract: COVID-19 has caused extensive human casualties with significant economic impacts around the globe, and has imposed new challenges on health systems worldwide. When the genetic sequence of SARS-CoV-2 was revealed, global vaccine companies and scientists have stepped forward to develop a vaccine, triggering a race toward vaccine development that the whole world is relying on. Several vaccines against SARS-CoV-2, the virus that causes COVID-19, have been developed. The first vaccines available in the US (by Pfizer-BioNTech and Moderna) are messenger RNA (mRNA) vaccines. Another mRNA vaccine is available in Europe (CureVac). Other vaccines (by Janssen-Johnson & Johnson, Astra-Zeneca, Sputnik-V, and CanSino) are made using human and primate adenovirus vectors. A third type of vaccine available outside of the US is an inactivated whole-virus SARS-CoV-2 vaccine (by Bharat Biotech, Sinopharm and Sinovac). An effective and safe vaccine could play a pivotal role in eradicating COVID-19. However, few important questions regarding SARS-CoV-2 vaccine development are explored in this review. The present review gives an insight into the current status of vaccine development and associated outcomes reported at different phases of trial. Read more
6. Title: OVERTURE IN DEVELOPMENT, PROPERTIES AND CLINICAL ASPECTS OF BIOSURFACTANTS: AN REVIEW
Abstract: Biosurfactants are a basically assorted gathering of surface-dynamic substances created by microorganisms. They are amphiphiles, they comprise of two sections- a polar (hydrophilic) moiety and non-polar (hydrophobic) congregation. In spite of a colossal measure of examination work over the most recent twenty years on conserving the creation of biosurfactants, their business accomplishment when contrasted with their manufactured partners actually stays a financial test. Utilization of immobilized organic entity, utilization of NPs, strong state aging, coordinated aging, froth fractionation, and fill and draw method of activity could end up being other promising cycles for the upgraded modern creation of different biosurfactants. Utilization of natural, fortified waste substrates and biosurfactants coproduction with another modern efficient item should be all the more basically concentrated particularly in huge aging vessels. In present work, we have covered various physicochemical and clinical aspects of biosurfactants. Read more
The current issue of the journal is available at : https://www.aphinfo.com/ijmpbs/current-issue
